The Effect of Antioxidant Caffeic Acid Phenethyl Ester (cape) on Some Enzyme Activities in Cisplatin-induced Neurotoxicity in Rats
نویسندگان
چکیده
Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, (1) has been synthesized by esterification of caffeic acid (2). At a concentration of 10 μM, it completely blocks production of reactive oxygen species (ROS) in human neutrophils and the xantine/xantine oxidase system (3). Besides its well-known antioxidant activity (2,4). CAPE inhibits certain enzyme activities such as lipoxygenases, cyclooxygenase and glutathione S-transferase (GST) (5-7). CAPE has been reported to have anti-inflammatory (8), cytostatic (1), antiviral (9), antibacterial (10) and antifungal (11) properties. The antitumor drug cisplatin [Cisdichlorodiammineplatinum (II), CDDP] is widely used in the treatment of solid tumors. The major side effects renal toxicity, THE EFFECT OF ANTIOXIDANT CAFFEIC ACID PHENETHYL ESTER (CAPE) ON SOME ENZYME ACTIVITIES IN CISPLATIN-INDUCED NEUROTOXICITY IN RATS
منابع مشابه
Neuroprotective effects of propolis and caffeic acid phenethyl ester (CAPE) on the radiation-injured brain tissue (Neuroprotective effects of propolis and CAPE)
Background: Our purpose was to investigate propolis and its component caffeic acid phenethyl ester (CAPE) for their antioxidant effects on the brain tissue of rats exposed to ionizing radiation (IR). Materials and Methods: Fifty-four male albino Sprague-Dawley rats, divided into six groups, were designed as normal control group, cranial irradiation of 5 Gray alone, irradiation plus CAPE, irradi...
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Treatment with amiodarone, a commonly prescribed antidysrhythmic agent, is associated with pulmonary fibrosis (PF) which is a commonly progressive and untreatable dieases. Caffeic acid phenethyl ester (CAPE) is a phenolic antioxidant and an active anti-inflammatory, anticancer, antimicrobial and antioxidant component of propolis (bee glue; a resinous hive product collected by honey bees). In th...
متن کاملProtective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Amiodarone-Induced Pulmonary Fibrosis in Rat
Treatment with amiodarone, a commonly prescribed antidysrhythmic agent, is associated with pulmonary fibrosis (PF) which is a commonly progressive and untreatable dieases. Caffeic acid phenethyl ester (CAPE) is a phenolic antioxidant and an active anti-inflammatory, anticancer, antimicrobial and antioxidant component of propolis (bee glue; a resinous hive product collected by honey bees). In th...
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OBJECTIVE The aim of this study were to investigate a role of oxidative stress and the therapeutic efficacy of caffeic acid phenethyl ester (CAPE) in the pathogenesis of neurotoxicity induced by isoniazid and etambutol in a rat model. MATERIALS AND METHODS Male Sprague-Dawley rats were randomly divided into eight experimental groups: control, INH, ETM, INH+ETM, INH+CAPE, ETM+CAPE, INH+ETM+CAP...
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